The Commission is charged with implementing the Digital Markets Act (DMA). Based on economic and legal reasoning, this paper asks how the Commission can fulfil this challenging task effectively. We make recommendations about how the Commission might prioritize cases, design optimal internal work structures, maximize the compliance mechanism’s effectiveness, avoid reinventing at least some wheels by leaning on antitrust tools and knowledge, and leveraging the Commission’s concurrent antitrust and regulatory powers to ensure the speedy and effective resolution of current and future investigations.